NEW CUSTOMER?  Take 5% off with discount code: NewCustomer5 - FREE SHIPPING IN APRIL ON ALL PRODUCTS. New to the Shop: Select Integrative Therapeutics!

Shopping Cart

0 Items

Proflora 4R - 30 capsules

SKU: ND-B127
UPC: 899870002180
Size: 30 capsules
Manufacturer: Bio-Botanical Research


Additional Info:
Proflora 4R Bio-Botanical Research
  • Description
  • Product Reviews
  • Ingredients
  • Manufacturer Info

Bio-Botanical Research Proflora 4R - 30 capsules

Spore-forming probiotics are commensal bacteria found in our gastrointestinal tract, which occur naturally in healthy soil. Endospores are undamaged by antibiotic therapies and stomach acid, making them the perfect addition to Biocidin® protocols.

Evidence suggests that the increase of inflammatory gastrointestinal (GI) disorders and intestinal permeability may, in part, be attributed to a under-consumption of these vital spore-producing flora. The combination of Quercetin, Marshmallow Root, and Aloe Vera extract in Proflora 4R™ provide additional nutritional support for “leaky gut” and a healthy microbial balance, with just one capsule a day. Combined with Biocidin Proflora4R can be an even more powerful force to support your bodies health. If you're looking to know more about Biocidin our recent article What is Biocidin? The Biofilm, Pathogen Buster is just what you need. 

Storage Statement :

Store in a cool dry place.

Recommendations :

Take one capsule per day with meals or as directed by your healthcare practitioner. If you are pregnant, nursing, or taking medication, consult your healthcare practitioner before use. Keep out of reach of children. 



Frequently Asked Questions

Do any of the products contain gluten, artificial colors, flavors, sugar, soy, or dairy?
All of our products are made without common allergens, including gluten/wheat, dairy, eggs, fish, shellfish, peanuts, soy, and artificial ingredients (note, see FAQ specifically regarding tree nuts).

Our Biocidin® LSF contains sunflower phospholipid instead of soy. It is stabilized into the optimal nano-particulate size range for absorption with a small amount of tocophersolan, a vitamin E analog. Safety data exists for tocophersolan at 300 times the amount consumed within our products. The ethanol alcohol portion of the products is derived from potatoes, but ethanol alcohol does not contain residual starch, sugar, proteins, or peptides. Our probiotic does not contain dairy.

Do any of the products contain tree nuts?
The Biocidin® Liquid, Biocidin® LSF, Biocidin® Capsules, Biocidin® TS, Dentalcidin™, and Dentalcidin™ LS all contain black walnut hull and leaf, which may contain trace amounts of the black walnut nut protein. Therefore, these products would not be suitable for use by those with severe nut allergies, as determined by their healthcare provider.

Where do the product ingredients come from?
The herbs in all of the products are from European and U.S. sources, except for the those in the Biotonic™ formula, which are from China. The Chinese herbs are certified organic and rigorously tested for any impurities. All of the herbs are processed in California at a cGMP facility that is regulated by the FDA and has NSF certification.

Are the products vegan?
All of the products are vegan, with the exception of the Dentalcidin™ toothpaste, which contains the bee product, royal jelly, and our Vitamin D3+ whose source is lanolin from sheep's wool. 

What are the capsules made of for the G.I. Detox™+, Proflora 4R, and Biocidin encapsulated products?
Vegetarian cellulose capsules are used for all products that come in capsule form. The cellulose is sourced from poplar and pine trees (HPMC), and as such may not be suitable for anyone with a severe poplar or pine tree allergy. The capsules used for the Biocidin® also contain a small amount of titanium dioxide, which gives them their opaque white color.

My product doesn’t have an expiration date printed on it. When should I replace it?
The products have a manufacturing date printed on them (“MFG” followed by a date). Although the product may not have an expiration date, it is recommended to replace the product two years after the printed manufacturing date.

Approximately how many drops are contained in each bottle?
There are approximately 700 drops in each bottle of Biocidin® broad-spectrum Liquid Formula. There are approximately 100 servings in each bottle of Biocidin® Liposomal Formula (each serving meaning 1 pump, equivalent to about 5 drops of the liquid formula). There are approximately 1950 drops in each bottle of Biotonic™ Adaptogenic Tonic.

Product Storage / Transport

Are the products affected by severe weather conditions?
Do not allow the product to freeze, or to remain in an area above 90oF (32oC) for a prolonged period of time. In transit, the products may be exposed for short periods to temperatures higher or lower than recommended for storage, and this is not typically a problem.

How do I store the products?
Storing the products upright in a cool, dark place is ideal. They should be kept out of direct sunlight. There is no need to refrigerate the products, however, the liposomal Biocidin® (LSF) does contain oils that may keep longer if refrigerated after opening.

If I am instructed to make a dilution of Biocidin® LSF in water for a children’s or beginning level adult protocol, does the diluted mixture need to be covered and refrigerated?
Not when it will be consumed within a day. However, it is helpful to store the mixture in a lidded container to protect from dust and spills. If more of the diluted mixture is made than will be consumed in one day, than it should be refrigerated, and replaced at least every several days.

How can I keep the products from leaking while traveling?
When carrying Biocidin® LSF, be sure to engage the pump locking mechanism by turning the top to the left until it won’t depress. For the regular Biocidin® liquid, make sure the neck of the bottle is clean by wiping the threads off. It’s best to place the liquid products in a plastic bag while traveling, and to keep them upright as best as possible, to prevent leakage.

General Product Usage

Will these products “cure” me?
Nutritional supplements such as the herbal products made by Bio-Botanical Research, Inc. are not meant to diagnose, treat, cure or prevent any kind of disease or medical condition. The purpose of broad-spectrum nutritional supplements is to support the body and maintain health. These supplements are formulated to provide nutritional support.* For best results, contact an integrative healthcare provider, naturopath, or another practitioner familiar with nutritional and herbal supplement protocols.**

If I have missed taking Biocidin® before my meal, can I still take it after having eaten?
Although not ideal, you can take it with a full stomach. A little extra may be taken, to compensate for the hindered absorption. Please consult your practitioner for specific amounts. Taking Biocidin® 15-20 minutes prior to eating helps to maximize absorption, and is strongly suggested.

If I’ve missed taking G.I. Detox™+ on an empty stomach, can I take it after having eaten?
It is very important to wait an hour or more, until the stomach has emptied, to take the G.I. Detox™+. It is also advisable to wait another full hour, after taking G.I. Detox™+, before eating or drinking anything other than water. This helps to ensure that the G.I. Detox™+ is helping cleanse biofilm breakdown and not food nutrients, supplements, or medications. 

Will use of these products kill off my beneficial gut flora?
Preliminary research supporting the use of the  ingredients in the products in the amounts listed in the product Usage Guide has shown no significant reduction in beneficial gut flora. The use of a high-quality probiotic supplement like Proflora® 4R during the protocol is still highly recommended, as it supports the normal proliferation of healthy gut flora.

How should I take my probiotics during a Biocidin® protocol?
Most probiotics should be taken a minimum of two hours after taking Biocidin®, Olivirex®, or G.I. Detox™+. Taking probiotics before bed is preferable, if possible, to give them maximum proliferation time without food or supplement interference. Proflora® 4R does not need to be taken apart from Biocidin®, but should still be taken at least one hour apart from any Olivirex®, or G.I. Detox™+.

Can I take grapefruit seed extract while following a Biocidin® protocol?
Due to reports of GI tract upset when combining the two, we do not recommend taking grapefruit seed extract while following a Biocidin® protocol.

If I’ve used Biocidin® to balance my GI tract, but would like to take it annually or as maintenance, how long should I use it?
Under the supervision of your healthcare practitioner, you can take the Biocidin® for 4-8 weeks for an annual or semi-annual cleanse. G.I. Detox™+ and Proflora® 4R are highly recommended along with Biocidin®, to support this periodic GI cleansing.

Are your herbal products OK to take with antibiotic drugs?
Biocidin® and Olivirex® should generally be taken an hour apart from antibiotic drugs to avoid stomach upset. These herbal products are generally very safe and can actually support the body when used along with antibiotics. G.I. Detox™+ should always be taken a minimum of one hour away from any medications. Be sure to read the product insert for the drug in question to see which herbs are contraindicated, if any.

Should I stop taking my antibiotics?
Antibiotics are important drugs that are often very helpful and are a valid treatment option. We do not suggest that you stop taking a prescribed antibiotic drug unless directed to do so by a qualified medical professional.

1 Capsule Supplies:

Ingredient Amount Daily Value
Proprietary Probiotic Blend   *

3 Billion Spore Cells: Bacillus subtilis, HU58™ Bacillus coagulans, Bacillus clausii

Quercetin (Dimorphandra mollis (fruit)) 100 mg *
Marshmallow (Althea officinalis) root 100 mg *
Aloe Vera (Aloe Barbadensis) 200:1 extract 2 mg *
* Daily Value not established

Other Ingredients :

Microcrystalline cellulose, vegetable capsule (cellulose and water).



Bio-Botanical Research®, Inc. was founded in 1989 in response to the needs of physicians addressing opportunistic infections. The following year, Great Smokies Diagnostic Laboratories (now Genova) was sent a sample of Biocidin® by a physician and had it tested for sensitivity against bacteria and yeast species. They found that Biocidin® was “the most powerful natural inhibitor of pathogenic organisms” that they had tested, and that it was “equal or more effective than traditional therapies”. They began to refer physicians, and soon, many practitioners across the country were reporting outstanding clinical results.

In response to healthcare practitioners’ continued request for effective solutions to address problems associated with intestinal ecology, immune system dysregulation and detoxification, a selection of companion products were developed. 30 years later, Bio-Botanical Research®, Inc. is recognized as a leader in the field of natural medicine.

Dr. Rachel Fresco

Founding director, Dr. Rachel Fresco L. Ac., Ph.D., continues to use her extensive background in medical herbology, functional medicine, and clinical nutrition to develop innovative specialty products for health professional use. Dr. Fresco is a popular speaker on the topic of biofilms, microbiome balance, and systemic microbial challenges.


Our products are formulated by and are designed for health professionals. All botanicals used in our formulations are of the highest USP grade quality, are tested for purity, and come with Certificates of Analysis. There are no synthetic fillers or additives used, and all products are hypoallergenic and are free of artificial flavors and colorings. Vegi-caps are used rather than gelatin capsules in manufacturing all encapsulated products. Our manufacturing facilities are federally and state licensed to produce nutritional supplements, and are certified to follow Good Manufacturing Practices (cGMP’s), and regulated by the FDA.

Product testing using American Association of Analytical Chemists (AOAC) methods are the standard operating procedure. Independent laboratories are used to test for effectiveness, heavy metals and purity, and all products are tested in clinical usage by physicians before being added to our product line.