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MegaOmega Fish Oil Supplement by Microbiome Labs
Microbiome Labs MegaOmega is the most comprehensive, full-spectrum fish oil scientifically formulated to support a healthy gut microbiome. It offers a superior ratio of EPA, DHA, and the "forgotten" DPA, as well as naturally-occurring metabolites called pro-resolving mediators (PRMs) shown to support a healthy immune and inflammatory response. If you want to know more about Pro Resolving Mediators otherwise known as PRM's check out our Blog Post - "Firefighters of the Body - Specialized Pro-Resolving Mediators" for more information.
- Specifically formulated with higher EPA content than DHA content in order to support a healthy gut.
- Supports a healthy gut microbiome
Fish Oil For A Healthy Gut
There is no doubt that fish oils are beneficial to human health, but many fish oil supplements miss the mark when it comes to formulation. Furthermore, some fish oil products that claim to benefit the gut microbiome are actually formulated more for brain health than gut health based on their omega-3 ratios. Fish oil is indispensable in natural medicine, but it has been severely underutilized for digestive and intestinal health. A recent experimental study published in the Journal of Scientific Reports found that omega-3 supplementation increases microbial diversity, specifically Bifidobacterium, Akkermansia muciniphila, and Lactobacillus, and enhances the production of intestinal alkaline phosphatase (IAP) – an endogenous antimicrobial peptide that suppresses E. coli, detoxifies LPS, and balances gut microbiota.1 The primary omega-3 fatty acids include eicosapentanoic acid (EPA), docosahexanoic acid (DHA), and docosapentanoic acid (DPA) – each with unique health benefits to the host.
EPA is the most powerful omega-3 for supporting gut health and well-documented for its ability to protect intestinal mucosa and reduce oxidative damage in the gut.2 A recent experimental study published in the Journal of Scientific Reports found that EPA supplementation reduced levels of fecal calprotectin and improved mucosa production and goblet cell differentiation.
DHA is most known for its beneficial impact on brain health. One of DHA’s most important roles is the modulation of an important part of phospholipid membranes, known as phosphatidylserine (PS). This substance promotes healthy signal conduction and protects neuronal survival not only to cells in the brains but also to neurons in the GI tract.
DPA, also known as the “forgotten fatty acid”, is receiving more attention in the omega-3 family due to its unique ability to increase EPA and DHA tissue status, but it also supports a healthy gut by reducing pro-inflammatory cytokines and macroscopic damage.5,6 Supplementation with DPA can also inhibit inflammatory cyclooxygenase (COX) pathways, resulting in healthier cells and tissues.
PRMs, or pro-resolving mediators, are omega-3 derivatives that are responsible for terminating an inflammatory response and repairing damaged tissue through a process known as remediation.8 PRMs fall into four families: lipoxins, resolvins, protectins, and maresins. They resolve everyday inflammation by sequestering proinflammatory cytokines, clearing neutrophils and inflammatory debris, and increasing lymphatic removal of phagocytes following an inflammatory response.9
While the human body is able to convert omega-3’s to PRMs, the process is time-consuming and requires multiple steps to complete. Furthermore, it can be inhibited due to stress, disease, genetics, diet and lifestyle factors.10 Supplementation provides the body with an abundance of PRMs, so that remediation and tissue restoration can proceed quickly and without limitation.
2 softgels contain:
Total Fat 2.5g
Total PRMs 200mcg
---(including 18-HEPE, 17-HDHA and 14-HDHA)
Total Omega-3 Fatty Acids 1500mg
---EPA (Eicosapentaenoic Acid) 850mg
---DHA (Docosahexaenoic Acid) 450mg
---DPA (Docosapentaenoic Acid) 100mg
Ingredients: highly refined and concentrated Omega-3 marine oil (one or more of anchovy, squid, sardine, herring and mackerel), capsule shell (gelatin, glycerin, purified water), natural lemon flavor, natural mixed tocopherols.
Ages 8 and up: Take 2 softgels daily with a meal, or as directed by your healthcare practitioner.
Choking hazard. If you are pregnant, nursing, taking medications or have a medical condition, please consult your doctor before use. Keep out of the reach of children.
About Microbiome Labs
The origin story of Microbiome Labs is a classic tale of forging new frontiers, complete with discovery, adversity, and a leap of faith. Neither founder set out on a path to start his own supplement company, but through persistent curiosity Dr. Tom Bayne and Microbiologist Kiran Krishnan stumbled upon an amazing opportunity.
With a rich background in research, Kiran noticed that many supplement companies were lacking sufficient clinical data, which inspired him to design trials that were more affordable and fitting for the supplement industry. He then expanded his skill set into product development and formulation for a number of retail supplement companies. Eventually he was hired to study probiotics and discover what would become the next big probiotic in the industry: Bacillus spores.
Before Kiran discovered the spores, Dr. Tom took a step back from supplement manufacturing and settled into his own chiropractic practice. As his practice began to blossom, he found himself on the forefront of Functional Medicine, uniquely focused on his patients’ gut health. For years, probiotics had proven so ineffective and inconsistent that he eventually quit using them in his practice altogether – that is, until he saw the research that Kiran had uncovered.
With Dr. Tom’s clinical expertise and Kiran’s probiotic research, the serendipitous pair formulated the first all-spore probiotic known as MegaSporeBiotic. After a great deal of clinical validation, the team set out to launch the product in the practitioner market by attending medical conferences.
In 2014, the company exhibited at only 6 conferences and signed on a handful of new accounts. However, as the product sales began to grow, the company chose to reallocate the majority of the profits back into research, with only a minimal amount leftover for marketing. This unorthodox approach is far and away what continues to set Microbiome Labs apart from the rest of the supplement industry.
In doing so, Microbiome Labs hopes to encourage other supplement companies to follow suit, thereby raising the bar of the supplement industry as a whole. In 2018, Microbiome Labs attended over 148 conferences, initiated and/or completed 14 clinical trials, and provided key solutions to thousands of practitioners, changing over 344,000 lives… and counting.
Join us in our mission to Make Vibrant Health Accessible for All.
The Microbiome Labs Team