NEW CUSTOMER?  Take 5% off with discount code: NewCustomer5 - FREE SHIPPING IN APRIL ON ALL PRODUCTS. New to the Shop: Select Integrative Therapeutics!

Shopping Cart

0 Items

Biocidin LSF - 50 mL spray

Bio-Botanical Research Biocidin LSF
Back to List
SKU: ND-B128
UPC: 899870002159
Size: 50 mL spray
Manufacturer: Bio-Botanical Research


  • Description
  • Product Reviews
  • Ingredients
  • Manufacturer Info

Bio-Botanical Research Biocidin LSF - 50 mL spray

Broad-Spectrum Liposomal Formula

Lyme disease is on the rise, more than 300,000 new cases are reported each year. In chronic Lyme disease and other neurological conditions treatment is often more challenging, as pathogens can hide in the central nervous system, fatty tissues, or intra-cellularly, and are often part of a biofilm matrix. In Lyme, not only are Borrelia burgdorferi spirochetes present, other co-infections such as Babesia are also common.

We are very excited to be able to offer Liposomal delivery of our broad-spectrum Biocidin combination as specialized nutritional support. The formula uses liposomal technology to deliver Biocidin straight into the bloodstream and the lymph for rapid systemic immune support. Lyme-literate practitioners appreciate liposomal delivery of Biocidin for its enhanced intracellular uptake as demonstrated in our research. Physicians’ reports of reduction in pain and other symptoms in as little as 4-6 weeks of use have been very encouraging.

If you're looking to know more about Biocidin our recent article What is Biocidin? The Biofilm, Pathogen Buster is just what you need. 

Biocidin LSF Features:

  • Liposomal delivery for immediate systemic absorption and bioavailability from the oral cavity
  • Assists in the delivery of broad-spectrum botanicals to the central nervous system, a key benefit as nutritional support in Lyme disease or other microbial challenges outside the GI tract*
  • Researched for intracellular absorption of ingredients*
  • Enhances lymphatic circulation of therapeutic compounds*
  • Unilamellar vesicles encapsulating Biocidin® have an optimal particle size of 100 nanometers
  • Research indicates potential in addressing biofilms and chronic/resistant cases of imbalanced terrain*
  • Includes botanicals to assist detoxification pathways and to address inflammation*
  • To decrease possible die-off or detoxification-type reactions we always recommend concurrent usage of G.I. Detox™ with Biocidin®

What are Liposomes?

Liposomes are microscopic single to multi-layer spheres made of phospholipids, the basic building blocks of cell membranes. Liposomes demonstrate the ability to cross the blood-brain barrier, deposit their cargo intracellularly, and enhance lymphatic circulation of therapeutic compounds.

Additionally, the phospholipids which compose the liposomes fuse with and feed cell membranes. Providing phospholipids in this way ensures proper membrane function to facilitate the absorption of nutrients and the excretion of cellular waste products and toxins. However, all liposomes are not created equally.

Many liposomes on the market use a low grade of phospholipid such as raw lecithin instead of the high phosphatidyl choline phospholipids necessary for therapeutic grade liposomes. Manufacturing processes of lower grade products also use less expensive shear methods, which results in large (200-600 nanometer), poorly absorbed particles.

Biocidin® provides 100 nanometer or smaller particle size optimal for therapeutic use

Suggested Use By the Manufacturer:

1-3 pumps daily. Begin with 1 pump, gradually increase to 3 pumps per day or as directed. Hold under tongue 30 seconds before swallowing. Can be added to water. Best taken on an empty stomach 10 minutes before meals. As with regular Biocidin®, begin slowly and gradually increasing per tolerance to avoid detoxification reactions. Ask your health care professional when starting any new supplement.

BEGINNING USAGE FOR SENSITIVE INDIVIDUALS: Mix 1 pump with 5 oz of water. Each oz of the diluted mixture contains 1 drop of Biocidin®. Start with 1 tsp of the diluted mixture the first dose, hold under the tongue for 30 seconds. If no strong reaction is felt, take another tsp in 3 hours, for a total of 3 tsp the first day. The following day repeats the same way, gradually increasing the amount of mixture taken per tolerance. Work up to using the entire 5 oz of the mixture in one day. Very sensitive persons use 10 oz of water for a greater dilution.

If you are nursing, pregnant, or taking medication, consult with your healthcare practitioner before use. 

Usage for Dental Care

Swish with 2 pumps Biocidin® LSF for 2 minutes after brushing the teeth, three times per day. In our dental study this protocol was continued for 4 weeks, with tremendous results. Use Dentalcidin™, Biocidin toothpaste, or try oil pulling with Biocidin® LSF, for ongoing maintenance.


Not for use during pregnancy. Discontinue use should adverse reaction occur.

*These statements have not been evaluated by the Food and Drug Administration. (FDA) These products are not intended to diagnose, treat, cure or prevent any disease.


Frequently Asked Questions

Do any of the products contain gluten, artificial colors, flavors, sugar, soy, or dairy?
All of our products are made without common allergens, including gluten/wheat, dairy, eggs, fish, shellfish, peanuts, soy, and artificial ingredients (note, see FAQ specifically regarding tree nuts).

Our Biocidin® LSF contains sunflower phospholipid instead of soy. It is stabilized into the optimal nano-particulate size range for absorption with a small amount of tocophersolan, a vitamin E analog. Safety data exists for tocophersolan at 300 times the amount consumed within our products. The ethanol alcohol portion of the products is derived from potatoes, but ethanol alcohol does not contain residual starch, sugar, proteins, or peptides. Our probiotic does not contain dairy.

Do any of the products contain tree nuts?
The Biocidin® Liquid, Biocidin® LSF, Biocidin® Capsules, Biocidin® TS, Dentalcidin™, and Dentalcidin™ LS all contain black walnut hull and leaf, which may contain trace amounts of the black walnut nut protein. Therefore, these products would not be suitable for use by those with severe nut allergies, as determined by their healthcare provider.

Where do the product ingredients come from?
The herbs in all of the products are from European and U.S. sources, except for the those in the Biotonic™ formula, which are from China. The Chinese herbs are certified organic and rigorously tested for any impurities. All of the herbs are processed in California at a cGMP facility that is regulated by the FDA and has NSF certification.

Are the products vegan?
All of the products are vegan, with the exception of the Dentalcidin™ toothpaste, which contains the bee product, royal jelly, and our Vitamin D3+ whose source is lanolin from sheep's wool. 

What are the capsules made of for the G.I. Detox™+, Proflora 4R, and Biocidin encapsulated products?
Vegetarian cellulose capsules are used for all products that come in capsule form. The cellulose is sourced from poplar and pine trees (HPMC), and as such may not be suitable for anyone with a severe poplar or pine tree allergy. The capsules used for the Biocidin® also contain a small amount of titanium dioxide, which gives them their opaque white color.

My product doesn’t have an expiration date printed on it. When should I replace it?
The products have a manufacturing date printed on them (“MFG” followed by a date). Although the product may not have an expiration date, it is recommended to replace the product two years after the printed manufacturing date.

Approximately how many drops are contained in each bottle?
There are approximately 700 drops in each bottle of Biocidin® broad-spectrum Liquid Formula. There are approximately 100 servings in each bottle of Biocidin® Liposomal Formula (each serving meaning 1 pump, equivalent to about 5 drops of the liquid formula). There are approximately 1950 drops in each bottle of Biotonic™ Adaptogenic Tonic.

Product Storage / Transport

Are the products affected by severe weather conditions?
Do not allow the product to freeze, or to remain in an area above 90oF (32oC) for a prolonged period of time. In transit, the products may be exposed for short periods to temperatures higher or lower than recommended for storage, and this is not typically a problem.

How do I store the products?
Storing the products upright in a cool, dark place is ideal. They should be kept out of direct sunlight. There is no need to refrigerate the products, however, the liposomal Biocidin® (LSF) does contain oils that may keep longer if refrigerated after opening.

If I am instructed to make a dilution of Biocidin® LSF in water for a children’s or beginning level adult protocol, does the diluted mixture need to be covered and refrigerated?
Not when it will be consumed within a day. However, it is helpful to store the mixture in a lidded container to protect from dust and spills. If more of the diluted mixture is made than will be consumed in one day, than it should be refrigerated, and replaced at least every several days.

How can I keep the products from leaking while traveling?
When carrying Biocidin® LSF, be sure to engage the pump locking mechanism by turning the top to the left until it won’t depress. For the regular Biocidin® liquid, make sure the neck of the bottle is clean by wiping the threads off. It’s best to place the liquid products in a plastic bag while traveling, and to keep them upright as best as possible, to prevent leakage.

General Product Usage

Will these products “cure” me?
Nutritional supplements such as the herbal products made by Bio-Botanical Research, Inc. are not meant to diagnose, treat, cure or prevent any kind of disease or medical condition. The purpose of broad-spectrum nutritional supplements is to support the body and maintain health. These supplements are formulated to provide nutritional support.* For best results, contact an integrative healthcare provider, naturopath, or another practitioner familiar with nutritional and herbal supplement protocols.**

If I have missed taking Biocidin® before my meal, can I still take it after having eaten?
Although not ideal, you can take it with a full stomach. A little extra may be taken, to compensate for the hindered absorption. Please consult your practitioner for specific amounts. Taking Biocidin® 15-20 minutes prior to eating helps to maximize absorption, and is strongly suggested.

If I’ve missed taking G.I. Detox™+ on an empty stomach, can I take it after having eaten?
It is very important to wait an hour or more, until the stomach has emptied, to take the G.I. Detox™+. It is also advisable to wait another full hour, after taking G.I. Detox™+, before eating or drinking anything other than water. This helps to ensure that the G.I. Detox™+ is helping cleanse biofilm breakdown and not food nutrients, supplements, or medications. 

Will use of these products kill off my beneficial gut flora?
Preliminary research supporting the use of the  ingredients in the products in the amounts listed in the product Usage Guide has shown no significant reduction in beneficial gut flora. The use of a high-quality probiotic supplement like Proflora® 4R during the protocol is still highly recommended, as it supports the normal proliferation of healthy gut flora.

How should I take my probiotics during a Biocidin® protocol?
Most probiotics should be taken a minimum of two hours after taking Biocidin®, Olivirex®, or G.I. Detox™+. Taking probiotics before bed is preferable, if possible, to give them maximum proliferation time without food or supplement interference. Proflora® 4R does not need to be taken apart from Biocidin®, but should still be taken at least one hour apart from any Olivirex®, or G.I. Detox™+.

Can I take grapefruit seed extract while following a Biocidin® protocol?
Due to reports of GI tract upset when combining the two, we do not recommend taking grapefruit seed extract while following a Biocidin® protocol.

If I’ve used Biocidin® to balance my GI tract, but would like to take it annually or as maintenance, how long should I use it?
Under the supervision of your healthcare practitioner, you can take the Biocidin® for 4-8 weeks for an annual or semi-annual cleanse. G.I. Detox™+ and Proflora® 4R are highly recommended along with Biocidin®, to support this periodic GI cleansing.

Are your herbal products OK to take with antibiotic drugs?
Biocidin® and Olivirex® should generally be taken an hour apart from antibiotic drugs to avoid stomach upset. These herbal products are generally very safe and can actually support the body when used along with antibiotics. G.I. Detox™+ should always be taken a minimum of one hour away from any medications. Be sure to read the product insert for the drug in question to see which herbs are contraindicated, if any.

Should I stop taking my antibiotics?
Antibiotics are important drugs that are often very helpful and are a valid treatment option. We do not suggest that you stop taking a prescribed antibiotic drug unless directed to do so by a qualified medical professional.

Proprietary Herbal Blend: Bilberry extract, Noni, Milk Thistle, Echinacea (purpurea & angustifolia), Goldenseal, Shiitake, White Willow (bark), Garlic, Grapeseed extract, Black Walnut (hull and leaf), Raspberry, Fumitory, Gentian, Tea Tree oil, Galbanum oil, Lavender oil (plant and flower), Oregano oil (plant and flower). Phospholipids (from purified Sunflower Seed lecithin)

Other Ingredients: Water, Glycerin, Ethanol, Vitamin E (d-alpha tocopheryl, polyethylene glycol 1000 succinate)

Servings: 100



Bio-Botanical Research®, Inc. was founded in 1989 in response to the needs of physicians addressing opportunistic infections. The following year, Great Smokies Diagnostic Laboratories (now Genova) was sent a sample of Biocidin® by a physician and had it tested for sensitivity against bacteria and yeast species. They found that Biocidin® was “the most powerful natural inhibitor of pathogenic organisms” that they had tested, and that it was “equal or more effective than traditional therapies”. They began to refer physicians, and soon, many practitioners across the country were reporting outstanding clinical results.

In response to healthcare practitioners’ continued request for effective solutions to address problems associated with intestinal ecology, immune system dysregulation and detoxification, a selection of companion products were developed. 30 years later, Bio-Botanical Research®, Inc. is recognized as a leader in the field of natural medicine.

Dr. Rachel Fresco

Founding director, Dr. Rachel Fresco L. Ac., Ph.D., continues to use her extensive background in medical herbology, functional medicine, and clinical nutrition to develop innovative specialty products for health professional use. Dr. Fresco is a popular speaker on the topic of biofilms, microbiome balance, and systemic microbial challenges.


Our products are formulated by and are designed for health professionals. All botanicals used in our formulations are of the highest USP grade quality, are tested for purity, and come with Certificates of Analysis. There are no synthetic fillers or additives used, and all products are hypoallergenic and are free of artificial flavors and colorings. Vegi-caps are used rather than gelatin capsules in manufacturing all encapsulated products. Our manufacturing facilities are federally and state licensed to produce nutritional supplements, and are certified to follow Good Manufacturing Practices (cGMP’s), and regulated by the FDA.

Product testing using American Association of Analytical Chemists (AOAC) methods are the standard operating procedure. Independent laboratories are used to test for effectiveness, heavy metals and purity, and all products are tested in clinical usage by physicians before being added to our product line.