In a randomized double blind trial involving 75 individuals, Tinospora cordifolia provided significant support for a healthy immune response by maintaining normal nasal function as well as healthy neutrophil and eosinophil activity. Beta-1,3/1,6-glucan, a natural polysaccharide extracted from the cell wall of Saccharomyces cerevisiae, has demonstrated the potential to support overall immunity and to maintain healthy cytokine balance. A randomized double blind, placebo-controlled trial involving apple polyphenols reveals support for maintaining a healthy nasal lining and nasal function. Quercetin, hesperidin and vitamin C provide additional support for stabilizing mast cells and maintaining healthy histamine production. Nettles leaf offers a history of clinical and traditional use for maintaining healthy immune function in response to environmental triggers.